Abstract
Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. It is suspected that relative summating potential (SP) changes are different in listeners with CS. In this proof-of-concept study, young, normal-hearing adults were recruited and assigned to a low/high-risk group for having CS based on their extended audiograms (9-16 kHz). SPs to paired-clicks with varying inter-click intervals isolated non-refractory receptor components of cochlear activity. Abrupt increases in SPs to paired- vs single-clicks were observed in high-risk listeners. Critically, exaggerated SPs predicted speech-in-noise and subjective hearing abilities, suggesting relative SP changes to rapid clicks might help identify putative synaptopathic listeners.
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