Abstract
An experimental easily swallowable oral sustained-release dosage form of acetaminophen (APAP) that can be administered to patients every 12 hours was formulated and evaluated in 8 healthy, adult volunteers. The test product was compared to a well-characterized, commercially available immediate-release acetaminophen caplet. Multiple doses of these two products were administered to 8 healthy human subjects in a two-way cross-over design. Saliva samples were collected over a period of 24–48 h depending upon the administered treatment. The time course of acetaminophen concentrations in saliva was analyzed using non-compartmental methods. Results indicate that it is possible to maintain the desired therapeutic concentration over a 12-h dosing interval using the molded tablet dosage form.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
