Relative accuracy of the diagnostic components of noninvasive carotid arterial tests: A comparison of pulsed Doppler arteriography and spectrum analysis

Abstract

Pulsed Doppler ultrasonography (UA), sound spectrum analysis, and subjective interpretation of the audible signal are valuable methods for assessing carotid arterial disease; however, the relative contribution of each in making a diagnosis is disputed. To investigate this issue, 258 noninvasive carotid studies with measured x-ray comparisons were reviewed. Internal carotid spectra, UA images, and images combined with the technician's comments were each interpreted blindly by three independent readers. Percentage of stenosis was categorized into six groups: 0, 1% to 24%, 25% to 49%, 50% to 74%, 75% to 99%, and 100%. Each reader's assessment of the individual noninvasive components and his overall reading of the complete study were compared with x-ray findings and with those of the other two readers. The readings of the three observers were consistent within each diagnostic component (p < 0.001). For each reader, the technician's comments significantly improved the accuracy of ultrasonic imaging alone (p < 0.001). Spectrum analysis was as good as the image plus technician's comments and, for two of three readers, was better than the image alone (p < 0.001).