Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients

Beibei Wang,Haoyu Wang,Peiquan Li,Liangliang Wang,Hongli Liu,Jingbo Liu,Lihua Wang

doi:10.6061/clinics/2018/e679

Beibei Wang, Haoyu Wang + Show 5 more

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https://doi.org/10.6061/clinics/2018/e679

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Abstract

OBJECTIVE:This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients.METHODS:Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS:The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p<0.01). Serum IL-10 levels were positively correlated with PBCDT ratios (r=0.375, p<0.05). The 5-year patient survival rate was significantly higher in the low serum IL-10 group (64.2%) than in the high serum IL-10 group (42.8%, p=0.012).CONCLUSIONS:PBCDT ratios and serum IL-10 levels are related to CC activity. These factors are reciprocally related and influence one another, and both are involved in the development and progression of CC. Low IL-10 expression is beneficial regarding the survival of patients with CC.

Highlights

In the 21st century, there is a high incidence of cancer in women
peripheral blood CD4+CD25+ regulatory T cell (PBCDT) are a class of negatively regulated immune cells that are characteristically identified by the surface expression of CD4 and CD25
T cells that are positive for CD4 and CD25 are mainly produced in the thymus and may be produced during an immune response to a peripheral tolerogen through induction by TGF-b, ab T cell receptor signals, and cytokines

Summary

Introduction

In the 21st century, there is a high incidence of cancer in women. As one common malignant tumor in women, cervical cancer (CC) ranks third in terms of incidence among all malignant tumor types [1]. Cancer is one of the major causes of death in women. 130,000 people are newly diagnosed with CC in China each year, accounting for approximately 25% of all of the CC patients in the world [2]. If treatment is provided in the early stages of CC, patients have a 5-year survival rate of up to 90% [3]. The incidence of CC has significantly decreased. The mortality of CC has dropped significantly by more than 50%, mainly due to the diagnosis and treatment of early-stage CC [4].

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