Relationships of exercise timing with sleep, fatigue and rest-activity rhythms of lung cancer patients in Taiwan: An exploratory study.

Abstract

To explore the relationship of exercise timing (exercising close to bedtime, exercising in daylight and maintaining fixed exercise schedule) with sleep quality, fatigue and rest-activity rhythms among lung cancer patients in Taiwan. Results from 43 lung cancer patients who were assigned and adhered to the exercise intervention in a 12-week randomised controlled trial were analysed. The MD Anderson Symptom Inventory and Pittsburgh Sleep Quality Index (PSQI) were administered. Actigraphs were used to assess rest-activity rhythms (in-bed less than out-of-bed dichotomy index, I<O) and objective sleep parameters, including total sleep time (TST) and sleep onset latency (SOL). Patients who exercised >4hr before bedtime had significant improvement in fatigue (p<.0001), sleep quality (p=.012 for PSQI; p=.037 for TST; p=.017 for SOL) and rest-activity rhythms (p=.048 for I<O). Furthermore, patients who exercised with daylight exposure had a significant improvement in fatigue (p=.037) and sleep quality (p=.039 for PSQI). Exercising >4hr before bedtime with daylight exposure is associated with improvement in rest-activity rhythms, sleep quality and fatigue in lung cancer patients. The causal relationship requires further investigation with experimental design.