Abstract
We confirmed previous observations of a strong dependence of percentage free disopyramide on total drug concentration. Using ultrafiltration, the percentage free disopyramide increased from 22.2 to 54.2% as the total concentration of disopyramide, added to aliquots of a serum pool, was increased from 2 to 5 !J.g/ml. The variability of the binding of disopyramide to serum proteins was further established for 50 cardiac patients' sera with total disopyramide values ranging from 0.5 to 5.8 /lg/ml. Serum pH was adjusted to 7.4 just prior to preparation of the free drug fraction. The percentage free disopyramide ranged from 16.5 to 54%.
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