Abstract
Autism Spectrum Disorder is a term that is used to describe people who have difficulties communicating with others and limited actions repetitive actions. Autism could be caused by both genetic and environmental conditions, and the Shank3 gene in the Shank family is one of the high-risk genes that has been found as one of the factors. However, although a lot of researches have been done to find out the relationships between Shank3 and autism, it is known by only a few people. This article will briefly talk about autism and Shank3 and review how Shank3 mutation causes autism and the changes in the brain and behaviour.
Highlights
+ $PDO % %DUDN HW DO Shank3 mutation in a mouse model of autism leads to changes in the S-nitrosoproteome and affects key proteins involved in vesicle release and synaptic function LQ Molecular psychiatry
/ 4LQ . 0D HW DO Social deficits in Shank3deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition LQ Nature neuroscience
Summary
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