Relationships Between Serum Omentin-1, Bone Mineral Density And Physical Activity Levels In Older Women

Abstract

PURPOSE: The purposes of this study were 1) to explore the relationship between serum omentin-1 and bone mineral density in older women, and to further understand the effect of adipose tissue on bone mineral density. 2) to assess the relationship between omentin-1 and bone mineral density between low MVPA (moderate-to- vigorous physical activity) group and high MVPA group. 3) to investigate the relationships between omentin-1, bone mineral density and physical activity (PA) levels in older women. METHODS: One hundred older women (age = 64 ± 6 years; body mass index = 24.5 ± 3.2 kg/m2) participated in this study. We divided the subjects into overweight/obesity and normal weight group. Bone mineral density was measured by dual energy X-ray absorptiometry. Serum omentin-1 concentration was measured using enzyme linked immunosorbent assay. Actigraph GT3X-BT accelerometer was used to measure the levels of physical activity. Subjects were divided into two groups based on the mean of the minutes spent in MVPA (180 min/week), defined as low MVPA group (n = 44, body mass index = 24.8 ± 3.5 kg/m2) and high MVPA group (n = 56, body mass index = 24.3 ± 2.9 kg/m2). RESULTS: Femoral neck (0.819 ± 0.110 vs.0.763 ± 0.106 g/cm2, p < 0.05), trochanter (0.725 ± 0.096 vs.0.665 ± 0.103 g/cm2, p < 0.01), lumbar spine (1.022 ± 0.148 vs.0.871 ± 0.221 g/cm2, p < 0.01) in overweight/obesity group was significantly higher than in normal weight group. Serum omentin-1 was negatively correlated with femoral neck, Ward’s BMD, trochanter and lumbar spine (r = -0.254, -0.207, -0.315, -0.205, all p < 0.01) in all groups, respectively. The results showed that there was a significant negative correlation between femoral neck, Ward’s BMD, trochanter and lumbar spine (r = -0.335, -0.332, -0.380, -0.395, all p < 0.05) in high MVPA group. However, no significant correlation was found in low MVPA group (p > 0.05). CONCLUSIONS: Omentin-1 might play an important role in bone metabolism in older woman. The relationship between omentin-1 and bone mineral density might be regulated by the level of physical activity.