Abstract
The relationships between plasma rennin activity (PRA) and plasma aldosterone were evaluated in rats maintained on altered dietary sodium or potassium intake for 6 weeks. A bivariate method of analysis was utilized to determine the correlations between these two dependent variables in the presence and absence of anesthesia for blood collection. Sodium restriction had a direct stimulatory effect on both renin and aldosterone, and a high sodium diet had the opposite effect. A significant positive correlation was observed between PRA and plasma aldosterone with variations in dietary sodium intake either in the presence (r = 0.79, P < 0.001) or absence (r = 0.67, P < 0.001) of anesthesia for blood collection. With variations in dietary sodium intake, linear changes in PRA were accompanied by logarithmic changes in plasma aldosterone. Varying potassium intake caused a negative correlation between PRA and aldosterone. High potassium intake was accompanied by significant suppression of PRA and marked stimulation...
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