Abstract
Objective: This study aimed to examine the relationships between plasma endothelial 1 and urinary 2,3-dinor-6-keto-PGF1α and other biochemical variables in normal pregnancy, preeclampsia, and the nonpregnant state using multiple regression analysis.Methods: Plasma endothelin 1 and urinary 2,3-dinor-6-keto-PGF1α were measured after extraction by specific radioimmunoassays in 20 women with proteinuric preeclampsia and 28 normal pregnant women. The two pregnant groups were matched with each other for age and gestation before delivery, and for age with a group of nonpregnant women. Multiple regression analysis was used to create models for plasma endothelin 1 and 2,3-dinor-6-keto-PGF1α in the preeclamptic and normal pregnant groups and in the nonpregnant group.Results: Using plasma endothelin 1 as the dependent variable, a significantly negative correlation was found with urinary 2,3-dinor-6-keto-PGF1α and plasma albumin in the preeclamptic group, accounting for 53% of the variance in plasma endothelin. The s...
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