Abstract
ABSTRACTBACKGROUND: Repeated cigarette use in individuals generally occurs due to the craving for smoking. Orexin-leptin hormones and temperament character traits are thought to be important factors affecting nicotine craving.OBJECTIVE: The aims of this study were to determine orexin-leptin blood levels, which appear in nicotine deprivation, in health professionals who were diagnosed as having tobacco use disorder in accordance with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) and to assess the temperament-character traits of the same group and to provide biologic and psychotherapeutic data for the treatment of tobacco abuse.METHODS: The study sample consisted of faculty of medicine students and resident physicians who were smokers (n = 40). The control group comprised medical students and resident physicians who were non-smokers (n = 40). The Sociodemographic and Clinical Information Form, DSM-IV SCID-I Clinical Version, and Temperament and Character Inventory (TCI) we...
Highlights
Craving is recognized as a prominent feature of nicotine dependence [1,2]
Orexin and leptin are claimed to be effective in the craving stage in many substance use disorders, as well as tobacco use disorders
Differences were detected between the smokers and non-smokers in Temperament and Character Inventory (TCI) scale subgroups and in terms of orexin levels
Summary
It is temporarily suppressed by the administration of nicotine, but, over time, nicotine produces craving It is commonly the first symptom of dependence and can occur within days of initiating smoking in individuals who have no tolerance and who report no symptoms of nicotine withdrawal [3]. No statistically significant relations were determined between the SCS and plasma orexin and serum leptin levels in the smoking group. CONCLUSIONS/IMPORTANCE: Differences were detected between the smokers and nonsmokers in TCI scale subgroups and in terms of orexin levels. These results will greatly assist in the fight against craving that appears as a result of smoking cessation. A number of studies investigating monoaminergic mechanisms indirectly related to orexin and leptin are required to research temperament, which has a greater genetic burden
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