Abstract
BackgroundThere are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables.MethodsStudy participants without medications for hypertension, diabetes, or dyslipidemia {614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years} were randomly recruited from a single community at the time of their annual health examination. The association between lipid profiles (total cholesterol (T-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, T-C/HDL-C, TG/HDL-C, LDL-C/HDL-C ratio and MetS, Insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR), and serum HMW adiponectin were analyzed.ResultsIn multiple linear regression analysis, TG/HDL-C and T-C/HDL-C ratios as well as TG showed significantly strong associations with all three MetS-associated variables in both men and women. In men, the ROC curve analyses showed that the best marker for these variables was TG/HDL-C ratio, with the AUC for presence of MetS (AUC, 0.82; 95% CI, 0.77-0.87), HOMA-IR (AUC, 0.75; 95% CI, 0.70-0.80), and serum HMW adiponectin (AUC, 0.67; 95% CI, 0.63-0.71), respectively. The T-C/HDL-C ratio, TG, HDL-C, LDL-C/HDL-C ratio, and non-HDL-C also discriminated these markers; however all their AUC estimates were lower than TG/HDL-C ratio. These results were similar in women.ConclusionIn Japanese community-dwelling adults, lipid ratios of TG/HDL-C, T-C/HDL-C, LDL-C/HDL-C as well as TG and HDL-C were consistently associated with MetS, insulin resistance and serum HMW adiponectin. Lipid ratios may be used as reliable markers.
Highlights
There are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables
Metabolic syndrome (MetS) known as a clustering of cardiovascular risk factors associated with insulin resistance, hypertension, glucose intolerance, hypertriglyceridemia [1,2], and low levels of high-density lipoprotein cholesterol (HDL-C), is a major worldwide public health problem
We investigated how lipid profiles were associated with MetS, insulin resistance and serum high molecular weight (HMW) adiponectin in healthy Japanese adults
Summary
There are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables. Metabolic syndrome (MetS) known as a clustering of cardiovascular risk factors associated with insulin resistance, hypertension, glucose intolerance, hypertriglyceridemia [1,2], and low levels of high-density lipoprotein cholesterol (HDL-C), is a major worldwide public health problem. The high molecular weight (HMW) form binds most avidly to its receptors and is one of the important molecules activating metabolic role of adiponectin [10]. Dyslipidemia is another well-known risk factor for CVD, as well as a component of MetS, and the role of HDL-C, triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) are already established as predictors of CVD [11]. In Japanese community-dwelling persons, there are few studies to demonstrate the associations between these lipid profiles, especially the lipid ratios, with MetS, insulin resistance and serum HMW adiponectin
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