Relationships between growth, cyclic amp and tylosin production in two mutants of Streptomyces fradiae

Abstract

A mutant of S. fradiae producing higher amounts of tylosin than its parent also showed higher intracellular cAMP and DNA. Similarly the addition of chloroquine to producing cultures of the parent strain significantly increased the production of tylosin, cAMP, and DNA. The most likely hypothesis is that cAMP acts on tylosin production through a stimulation of the synthesis of DNA, which may prevent aging of the producing cells and lead to higher overvall antibiotic production.