Relationships between fat mass, plasma adipokines and bone in post-menopausal caucasian women

Abstract

Event Abstract Back to Event Relationships between fat mass, plasma adipokines and bone in post-menopausal caucasian women KA Ward1*, REB Webb1, A Prentice1 and GR Goldberg1 1 MRC Human Nutrition Research, United Kingdom Until recently, obesity was assumed to protect against fragility fracture and was attributed to weight-bearing effects of excess adipose tissue. However, adipokines, secretory products of adipose tissue, may have independent adverse or beneficial effects on bone. The high prevalence of obesity in many populations, together with recent findings in the UK of a high prevalence of obese fragility fracture patients with normal BMD, and increased fracture risk in obese children, indicate that studies are needed to establish bone phenotype in obesity.We investigated relationships between adipokines and bone independently of body weight and composition in a group of 70 post-menopausal women of a wide range of BMI and adiposity: mean±SD (range) age 62.3±3.7 y (55.5-70.9); weight 67.5±11.3 kg (49.2-100.0); BMI 24.9±3.8 kg/m2 (17.6-33.3). Whole-body, hip, spine and forearm DXA scans were taken. Size-adjusted BMC (SA-BMC) was generated by adjusting for bone area, weight and height. Total body fat mass (TBFM) was measured using a 4-compartment model (total-body water [deuterium dilution], total BMC [DXA], body volume [air-displacement plethysmography], body weight). Fasting plasma concentrations of leptin, total and high-molecular weight (HMW) adiponectin were measured.Relationships were examined using univariate and multiple regression analyses. All measures were transformed into natural logarithms. Total adiponectin was retained in regression models regardless of significance.Mean TBFM was 26.5±8.9 kg (11.6–49.2). There were significant associations between TBFM and leptin (0.838), TBFM and adiponectin (-0.333), adiponectin and weight (-0.402), and adiponectin and leptin (-0.433). Fat mass was a predictor of radius (P=0.0008) and forearm (P=0.04) SA-BMC. Leptin was a predictor of radius SA-BMC (0.05). SA-BMC at several forearm sites (P=0.02-0.003), trochanter (P=0.01), hip shaft (P=0.04) and whole-body (P=0.05) was negatively associated with total adiponectin. SA-BMC of the forearm (p=0.01) and trochanter (p=0.03) was negatively related to HMW adiponectin.In contrast to leptin, adiponectin was negatively associated with SA-BMC irrespective of whether TBFM was also associated with the same measure. These findings suggest that relationships between adiponectin and bone are more than simply those of a marker of TBFM. Keywords: Bones, Bone Research Conference: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society, Cambridge, United Kingdom, 27 Jun - 29 Jun, 2011. Presentation Type: Oral Topic: Abstracts Citation: Ward K, Webb R, Prentice A and Goldberg G (2011). Relationships between fat mass, plasma adipokines and bone in post-menopausal caucasian women. Front. Endocrinol. Conference Abstract: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society. doi: 10.3389/conf.fendo.2011.02.00073 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2011; Published Online: 30 Sep 2011. * Correspondence: Dr. KA Ward, MRC Human Nutrition Research, Cambridge, United Kingdom, kw@mrc.soton.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers KA Ward REB Webb A Prentice GR Goldberg Google KA Ward REB Webb A Prentice GR Goldberg Google Scholar KA Ward REB Webb A Prentice GR Goldberg PubMed KA Ward REB Webb A Prentice GR Goldberg Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.