Abstract
Statistical correlations have been examined between two experimental carcinogenicity indices, a mutagenicity index, and several theoretical reactivity indices for a sample of polycyclic aromatic hydrocarbons displaying a considerable range of carcinogenic activities. Salmonella/microsome mutagenicity assay results show no quantitative correlation with either lball indices (r = 0.08) or a mouse-skin tumor index (r = −0.11) for this sample, whereas the two carcinogenicity indices show reasonable agreement (r = 0.84). The theoretical indices, which represent chemical reactivities for several putative carcinogenic “activation” steps, correlate with the cancer indices ( r ∼ 0.6–0.9). but not the mutagenicity index, suggesting a usefulness in cancer prescreening procedures. Similar results are found for a sample of 24 unsubstituted aromatic hydrocarbons. Available hamster V79 cell assay results show good correlations with the carcinogenicity indices (r = 0.87–0.99).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
