Abstract
The papers in this section document the following points: many different types of damage to DNA may be repaired; a number of completely different types of damage to DNA may be repaired; chemical and physical carcinogens damage DNA, as indicated by direct observation and by the fact that they provoke the sequence of repair steps in DNA; and the use of xeroderma pigmentosum cells, the analogue of excision-deficient bacterial cells, emphasizes the utility of investigating the effects of chemical carcinogens on human cells. Three large problems remain. The first is the biochemical nature of the complementation process among the various XP groups. The second is the nature of the physical or chemical damage to DNA that results in neoplastic transformation. To date, this is easily approachable only for uv irradiation. The third is the detailed molecular mechanisms by which changes in DNA appear as neoplastic transformation. (auth)
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