Relationship study between plasma orphanin FQ and affective disorder

Abstract

Objective To investigate the pathogenesis and diagnosis of affective disorder through studying the changes of plasma orphanin FQ (OFQ) level in patients with affective disorder. Methods 24 patients with major depressive disorder (M D group) ,21 patients with Bipolar Ⅱ depression (BD group ), 26 patients with Bipolar Ⅰ mania (BM group) and 31 healthy volunteers(control group)were studied. The concentrations of plasma orpha-nin FQ were measured by radioimmunoassay (RIA). Results 1. The plasma OFQ concentration was (17.20±4.13)ng/L in MD group, (20.16±3.58) ng/L in BD group, (11.29±3.28) ng/L in BM group and (13.92±4.53) ng/L in control group. Compared with the control group,the levels of plasma OFQ in MD and BD group were higher(t=2.76, t=5.28; P<0.01),while the level in BM group was lower( t=2.47, P<0.05). The differences were statistically significant. 2. The levels of plasma OFQ in MD and BD group were positively correla-ted to HAMD and MADRS( r = 0. 598, P <0.01;r=0.646, P < 0.05). And there was a significantly negative correlation between the OFQ level and BRMS in BM group( r= -0. 750, P<0.01 ). Conclusion The changes of plasma OFQ level may play an important role in the pathogenesis of affective disorder and indicate the severity of disease. Key words: Affective Disorder; Depression; Mania; Orphanin FQ