Abstract
Adenine phosphoribosyltransferase (APRT) is a key component of the nucleotide salvage pathway converting free adenine plus 5′-phospho-ribosylpyrophosphate (PRPP) to 5′-adenosine monophosphate (AMP) plus pyrophosphate. This enzyme is ubiquitous in all organisms examined. In some parasitic organisms, which lack a de novo purine synthesis, APRT is the only means by which AMP is formed.1 APRT deficiency in humans and mice leads to the accumulation of highly insoluble 2,8-dihydroxy adenine.2,3 This can lead to kidney stones and possible kidney failure.2,3
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