Relationship of teicoplanin MICs to treatment failure in teicoplanin-treated patients with methicillin-resistant Staphylococcus aureus pneumonia

Abstract

The objective of this study was to determine the predictive value of teicoplanin minimal inhibitory concentrations (MICs) for treatment failure among patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. In this study, all patients with ≥1 tracheal aspirates or sputum cultures positive for MRSA admitted to the hospital between April 2011 and September 2011 were reviewed. We enrolled patients who are ≥18 years of age, with a diagnosis of pneumonia, and with a receipt of teicoplanin therapy throughout the course. The relationship between teicoplanin Etest MICs and treatment outcomes of MRSA pneumonia was analyzed to identify the breakpoint of teicoplanin MICs influencing treatment outcomes. Of the 80 patients enrolled, 31 had a lower teicoplanin MIC level (<2.0mg/L) and 49 had a higher MIC level (≥2.0mg/L) for MRSA. The lower MIC group had a higher clinical resolution rate in 14 days [24 (77.4%) vs. 23 (46.9%), p=0.007] and a lower treatment failure rate at the end of teicoplanin treatment [4 (12.9%) vs. 18 (36.7%), p=0.020]. A comparison between the treatment success and failure groups showed that the former had a longer duration of teicoplanin use (18.76±10.34vs.12.41±5.65 days; p=0.014). Results of a multivariate analysis showed that teicoplanin MICs≥2.0mg/Land shorter duration of teicoplanin therapy were independent risk factors for treatment failure. A higher teicoplanin MIC value (≥2.0mg/L) may predict the treatment failure among patients with teicoplanin-treated MRSA pneumonia.