Abstract
BackgroundVitamin D deficiency is a prevalent condition that is found in about 30–50% of the general population, and it is increasing as a new risk factor for coronary artery disease. Our study aimed to evaluate the relationship of serum vitamin D levels with coronary thrombus burden, Thrombolysis In Myocardial Infarction flow grade, and myocardial blush grade in patients managed by primary percutaneous coronary intervention for their first acute ST-segment elevation myocardial infarction.ResultsEighty patients were included in the study with their first acute ST-segment elevation myocardial infarction and were managed by primary percutaneous coronary intervention. According to the serum concentrations of vitamin D, the study population was divided into 2 groups: group A with abnormal vitamin D levels less than 30 ng/ml (50 patients) and group B with normal vitamin D levels equal to or more than 30 ng/ml (30 patients). Angiographic data was recorded before and after coronary intervention. On comparing thrombus grade and initial and post-procedural Thrombolysis In Myocardial Infarction flow between both groups of patients, there was no significant difference (p = 0.327, p = 0.692, p = 0.397). However, myocardial blush grade was better in patients with normal vitamin D levels (p = 0.029) without a significant correlation between vitamin D concentration values and myocardial blush grade (r = 0.164, p = 0.146).ConclusionsPatients with first acute ST-segment elevation myocardial infarction and normal vitamin D levels undergoing primary percutaneous coronary intervention had better myocardial blush grade and more successful microvascular reperfusion in comparison with patients with abnormal vitamin D levels. There was no significant difference between the normal and abnormal vitamin D groups regarding the coronary thrombus grade and Thrombolysis In Myocardial Infarction flow.
Highlights
Vitamin D deficiency is a prevalent condition that is found in about 30–50% of the general population, and it is increasing as a new risk factor for coronary artery disease
The prevalence of vitamin D deficiency was estimated to be approximately 30–50% of the general population [4], and several studies have shown an association between vitamin D deficiency and cardiovascular diseases (CVD) including hypertension (HTN), acute myocardial infarction (AMI), heart failure, coronary artery diseases (CAD), metabolic syndrome, and diabetes mellitus (DM) [5]
This study aimed to evaluate serum vitamin D level’s relationship with coronary thrombus grade, Thrombolysis In Myocardial Infarction (TIMI) flow, and myocardial blush grade (MBG) in patients with first acute segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)
Summary
Vitamin D deficiency is a prevalent condition that is found in about 30–50% of the general population, and it is increasing as a new risk factor for coronary artery disease. Our study aimed to evaluate the relationship of serum vitamin D levels with coronary thrombus burden, Thrombolysis In Myocardial Infarction flow grade, and myocardial blush grade in patients managed by primary percutaneous coronary intervention for their first acute ST-segment elevation myocardial infarction. The prevalence of vitamin D deficiency was estimated to be approximately 30–50% of the general population [4], and several studies have shown an association between vitamin D deficiency and cardiovascular diseases (CVD) including hypertension (HTN), acute myocardial infarction (AMI), heart failure, CAD, metabolic syndrome, and diabetes mellitus (DM) [5]. This study aimed to evaluate serum vitamin D level’s relationship with coronary thrombus grade, Thrombolysis In Myocardial Infarction (TIMI) flow, and myocardial blush grade (MBG) in patients with first acute STEMI undergoing primary PCI
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