Abstract
Introduction: Irisin is a myokine secreted from the skeletal muscle. Preliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), particularly in hemodialysis patients. Objectives: This study aimed to examine the relationship between serum irisin level and different demographic and biochemical factors in non-diabetic hemodialysis patients. Patients and Methods: This study was conducted on 61 non-diabetic stable hemodialysis patients. Serum level of irisin was measured by ELISA method. Demographic information was recorded for all subjects. In addition, biochemical factors were assessed using standard methods. Results: In this study serum irisin level was 8.15±4.24 ng/mL. There were positive correlations of serum irisin with gender (P=0.014) (higher serum value of irisin in males) and hemodialysis doses (r=0.32, P=0.01). Additionally, a negative correlation of serum irisin with body mass index (BMI) was detected (r= 0.26, P=0.036). Conclusion: The positive correlation of serum irisin with hemodialysis doses and a negative correlation of serum irisin with BMI requires further investigations in other patients with more patients.
Highlights
IntroductionPreliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), in hemodialysis patients
Irisin is a myokine secreted from the skeletal muscle
The purpose of the present study is to investigate the relationship between serum irisin level and various demographic and biochemical factors in non-diabetic hemodialysis patients
Summary
Preliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), in hemodialysis patients. Objectives: This study aimed to examine the relationship between serum irisin level and different demographic and biochemical factors in non-diabetic hemodialysis patients. Patients and Methods: This study was conducted on 61 non-diabetic stable hemodialysis patients. Serum level of irisin was measured by ELISA method. Results: In this study serum irisin level was 8.15±4.24 ng/mL. There were positive correlations of serum irisin with gender (P = 0.014) (higher serum value of irisin in males) and hemodialysis doses (r=0.32, P = 0.01). Conclusion: The positive correlation of serum irisin with hemodialysis doses and a negative correlation of serum irisin with BMI requires further investigations in other patients with more patients. Irisin is a newly discovered myokine that released into the circulation through cleavage of fibronectin type III domain containing
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