Relationship of serum irisin levels and various demographic and biochemical factors in non-diabetic hemodialysis patients

Abstract

Introduction: Irisin is a myokine secreted from the skeletal muscle. Preliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), particularly in hemodialysis patients. Objectives: This study aimed to examine the relationship between serum irisin level and different demographic and biochemical factors in non-diabetic hemodialysis patients. Patients and Methods: This study was conducted on 61 non-diabetic stable hemodialysis patients. Serum level of irisin was measured by ELISA method. Demographic information was recorded for all subjects. In addition, biochemical factors were assessed using standard methods. Results: In this study serum irisin level was 8.15±4.24 ng/mL. There were positive correlations of serum irisin with gender (P=0.014) (higher serum value of irisin in males) and hemodialysis doses (r=0.32, P=0.01). Additionally, a negative correlation of serum irisin with body mass index (BMI) was detected (r= 0.26, P=0.036). Conclusion: The positive correlation of serum irisin with hemodialysis doses and a negative correlation of serum irisin with BMI requires further investigations in other patients with more patients.