Abstract
BackgroundDental caries is a chronic disease among children and there is need for studies assessing the caries risk factors using saliva. This study aimed to evaluate the association of salivary soluble CD14 and dental caries in young children.Material and MethodsA cross-sectional study was done among 300, 3-6 year old school children of Udupi district. A total of 40 children who were caries free, with no past systemic illness or craniofacial anomalies and 40 children with dental caries with no history of dental treatment for caries, with no past systemic illness or craniofacial anomalies were included in control and test groups respectively. Salivary CD14 was evaluated using ELISA test.ResultsThe mean salivary soluble CD14 concentration was significantly higher in caries free (1.34±0.35 µg/ml) children than caries experienced (0.54±0.36 µg/ml) (p<0.001). There was significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.868, P< 0.001) among all the children. Similarly, sub-group analysis of caries experienced children also showed significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.774, P<0.001).ConclusionsResults obtained in our study suggested that salivary CD14 can be a indicator of dental caries in young children. Key words:Caries, CD14, Children, Saliva.
Highlights
Dental caries is the most prevalent dental disease affecting mankind
We aimed to evaluate the association between salivary CD14 and dental caries experience
Biria et al [9] reported that the difference in the result could be due to the variation in the age groups since specific immune responses have not yet been developed completely in 3-5 year old children, the increase in sCD14 level in saliva may be a reparative response of immune system to the inadequacy of such immunoglobulins as IgA and IgG
Summary
Dental caries is the most prevalent dental disease affecting mankind. A remarkable reduction in the prevalence and severity of caries has been observed in many countries over recent decades. Dental caries is a chronic disease among children and there is need for studies assessing the caries risk factors using saliva. This study aimed to evaluate the association of salivary soluble CD14 and dental caries in young children. Results: The mean salivary soluble CD14 concentration was significantly higher in caries free (1.34±0.35 μg/ml) children than caries experienced (0.54±0.36 μg/ml) (p
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