Relationship of psoriasis with microecology of the skin and intestine

Abstract

Psoriasis is a chronic, non-infective inflammatory dermatosis characterized by erythemas covered with scales. Psoriasis is considered as a systemic disease, and several studies have confirmed that it is associated with many other diseases, such as cardiovascular diseases, obesity, diabetes mellitus type Ⅱ, dyslipidemia, nonalcoholic fatty liver disease, anxiety disorder, depression and inflammatory bowel disease. The occurrence and development of psoriasis is closely related to the immune response, and the immune dysfunction of T lymphocytes induced by the infiltration and activation of inflammatory cells has been confirmed as the key step in the pathogenesis of psoriasis. Various kinds of cytokines in the local microenvironment can promote the activation and proliferation of T lymphocytes, and regulate the differentiation of T lymphocytes into different subsets, which take an important part in the occurrence of psoriasis. In recent years, researchers have found that local microbes also play an important role in this process. Thus, this review summarizes the progress in the roles of human skin and gut microbiota in psoriasis. Key words: Psoriasis; Intestines; Microbial consortia; Immunity