Abstract
Methods Forty nine subjects undergoing clinically indicated right and left heart cardiac catheterization were prospectively recruited to undergo MRI in a 1.5T scanner. First pass perfusion using steady state free precession saturation recovery sequence was performed with gadolinium infusion at 0.01 mmol/kg. Global TT was defined as the time between the peaks of time intensity curves between the right atrium and the ascending aorta. Segmental TT included TT between right atrium to pulmonary artery (right heart TT), pulmonary artery to left atrium (pulmonary TT), or left atrium to ascending aorta (left heart TT). All TTs were normalized to heart rate. Multivariate regression analysis was performed to delineate the relationship of hemodynamic parameters measured during cardiac catheterization to TT. Receiver operating characteristic (ROC) analyses were performed to assess ability of global and segmental TT to predict elevated LVEDP.
Highlights
Normalized mean transit time (TT) in the left atrium has previously been shown to approximate left ventricular end diastolic pressure (LVEDP)
Pulmonary and left heart TTs were significantly prolonged in patients with elevated LVEDP compared to patients with LVEDP
In multivariate regression analysis adjusting right atrial pressure, pulmonary artery (PA) peak systolic and mean pressure, pulmonary vascular resistance, LVEDP and PA oxygen saturation, global TT was most significantly associated with LVEDP (p
Summary
Normalized mean transit time (TT) in the left atrium has previously been shown to approximate left ventricular end diastolic pressure (LVEDP). We characterized global and segmental central circulatory TT, in patients with and without systolic dysfunction, and delineated the relationship of TT to hemodynamics
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