Abstract
Background MicroRNAs (miRs) are small non-coding molecules that regulate gene expression post-transcriptionally by promoting translational repression or degradation of target mRNAs. Altered expression as well as mutations in the sequences of miRs or their target sites have been related to a great number of diseases, including diabetes and its complications. The G allele of the rs531564 (C>G) polymorphism in miR-124 gene was already associated with increased risk of type 2 diabetes mellitus (T2D) and the A allele of the rs4636297 (G>A) polymorphism of miR-126 gene was associated with severity of diabetic retinopathy (DR).
Highlights
MicroRNAs are small non-coding molecules that regulate gene expression post-transcriptionally by promoting translational repression or degradation of target mRNAs
The G allele of the rs531564 (C>G) polymorphism in miR-124 gene was already associated with increased risk of type 2 diabetes mellitus (T2D) and the A allele of the rs4636297 (G>A) polymorphism of miR-126 gene was associated with severity of diabetic retinopathy (DR)
The minor allele frequency of miR-124 was 10% in patients without DR, 13% in nonproliferative DR and 14% in proliferative DR (p=0.349); and the minor allele frequency of miR-126 was quite similar in the three groups of T2D patients, approximately 43% (p=0.925)
Summary
MicroRNAs (miRs) are small non-coding molecules that regulate gene expression post-transcriptionally by promoting translational repression or degradation of target mRNAs. The G allele of the rs531564 (C>G) polymorphism in miR-124 gene was already associated with increased risk of type 2 diabetes mellitus (T2D) and the A allele of the rs4636297 (G>A) polymorphism of miR-126 gene was associated with severity of diabetic retinopathy (DR)
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