Abstract
The relationship between PAT activity and t-PA antigen concentration and their dependence on age, sex, body mass index, lipoprotein metabolism parameters and life style was studied in a subpopulation of the DRECAN Study. PAT activity and t-PA concentration showed a similar dependence on age and sex. The ratio PAI activity/t-PA concentration correlated much better with PAT activity than with t-PA concentration. PAT activity and t-PA concentration were equally strong correlated with body mass index and triglyceride concentration. Both fibrinolytic variables showed no significant differences between smokers and non-smokers. PAT activity as well as t-PA concentration were lower in users of oral contraceptives than in non-users. This result was independent of the relationship between BMI as well as triglyceride concentration on PAT activity and t-PA concentration and not the only responsible factor for the higher PAT and t-PA values in men compared to women. The amount of alcohol and beer per day was a significantly influential factor on PAT activity in men. The high PAT activity in middle-aged men is possibly connected with the described higher prevalence of elevated PAT activity in young postinfarction patients compared with unselected patients.
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