Abstract
Adiponectin is an adipocyte specific cytokine which, in contrast to other adipokines, has been described to have antiinflammatory, antithrombotic, and anti-atherogenic properties. This study evaluates the association between plasma adiponectin levels with acute coronary syndrome (ACS) and angiographic coronary lesion severity in Indian population. Ninety patients included in the study were divided in two groups in 1 : 1 ratio—patients admitted with a diagnosis of ACS and those without ACS. Adiponectin and other risk markers are measured in forty-five consecutive patients in each group undergoing coronary angiography. Patients without ACS were found to have higher adiponectin (16.47 ± 7.88 μg/mL) levels than patients with ACS (9.03 ± 3.13 μg/mL) (P < 0.001). In multiple regression analysis adjusted for all other risk markers, higher adiponectin levels remain positively associated with a lower risk of ACS (P value > 0.002). The greatest increase in risk for ACS was seen at adiponectin levels ≤12.20 μg/mL in study subjects. The adiponectin levels were inversely related to the angiographic severity of coronary artery stenosis increases (P value > 0.02). The study concluded that higher adiponectin levels are independently associated with lower risk of ACS, and patients with severe angiographic coronary artery disease have lower levels of adiponectin.
Highlights
Obesity is pandemic in industrialized and south Asian countries and has been implicated as a major cause of cardiovascular morbidity and mortality [1,2,3,4]
The study group consisted of 90 patients of coronary artery disease, and these patients were divided into two subgroups—with (n = 45) and without acute coronary syndrome (ACS) (n = 45)
Since this study was designed to look for newer risk factors in Indian subjects, so it was decided to exclude those known risk factors very strongly associated with ACS risk and increased coronary lesion severity
Summary
Obesity is pandemic in industrialized and south Asian countries and has been implicated as a major cause of cardiovascular morbidity and mortality [1,2,3,4]. Adipocyte has an active endocrine function, as it produces several cytokines: interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and adiponectin that is a 30 kDa adipocyte complement-related protein These cytokines may directly contribute to the development of obesity-related diseases, such as diabetes mellitus, dyslipidemia, hypertension, and atherosclerotic vascular disease [5, 6]. Adiponectin is an adipocyte specific cytokine which, in contrast to other adipokines, has been described to have antiinflammatory, antithrombotic, and anti-atherogenic properties [7,8,9,10] It is abundant in the plasma of normal subjects, but it decreased in conditions such as obesity [11] and type diabetes mellitus [12]. Whether adiponectin is an independent risk factor in this signaling network or is mainly associated with other inflammatory proteins such as IL-6 or C-reactive
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
