Relationship of ocular disease activities before and after starting infliximab using Behçet's disease ocular attack score 24

Abstract

Listen

Translate article

SummaryPurposeTo investigate the relationship of ocular disease activities before and after starting infliximab using Behçet's disease ocular attack score 24 (BOS24).Patients and MethodsWe studied 69 eyes of 35 patients with ocular Behçet's disease (BD) who had started infliximab therapy. Total BOS24 scores during 1‐year period (BOS24‐1Y) before and after starting infliximab therapy were calculated and its correlation was examined. Patients were divided into three group according to the BOS24‐1Y before starting infliximab; H group (BOS24‐1Y of 40 points or more, n = 14), M group (20 to 39 points, n = 12) and L group (19 points or less, n = 9). Ocular disease activities after starting infliximab were compared among three groups.ResultsSignificant correlation was observed between BOS24‐1Y scores before and after starting infliximab (P < 0.0001). BOS24‐1Y after starting infliximab in H, M and L group were 20.9 ± 28.3, 7.3 ± 15.2, 0.6±1.9 points, respectively (P < 0.05). After starting infliximab, ocular attacks were disappeared in 8 cases (89%) in L group, whereas severe ocular attacks still occurred in 7 cases (50%) in H group.ConclusionsBOS24‐1Y before starting infliximab could be a predictor for disease activity after starting infliximab.