Abstract
Vitamin K-dependent Protein C recently isolated by Stenflo ( J. Biol. Chem. 251, 355, 1976) was found to be related to autoprothrombin II-A by comparing amino acid analysis, molecular weight, immunochemical properties, and inhibitory activity in blood coagulation. Our purified Protein C converted to autoprothrombin II-A with purified thrombin in association with loss of a small peptide(s). Protein C or autoprothrombin II-A served as cofactors for epinephrine induced platelet aggregation in platelet rich plasma taken from dogs heavily dosed with warfarin. It is suggested that the designation Factor XIV be assigned to Protein C and Factor XIVa to autoprothrombin II-A with the following meaning: Factor XIV Thrombin Factor XIVa
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