Abstract
Disturbance in vascular functioning pathways has been related to pathophysiology of migraine. The present study investigated the role of MTHFR C677T and ACE I/D gene polymorphisms in migraine susceptibility within the population of Jammu province of J&K state. A sum of 252 subjects including 102 migraine patients and 150 non-migrainous unrelated healthy controls were enrolled for the present study. PCR-RFLP was performed for determining MTHFR gene variations. For detecting insertion/deletion in ACE gene PCR was performed. In case of MTHFR, ‘T’ allele (variant allele) and TT genotype (variant) was found to be present only in migraine patients but not in controls thereby suggesting its positive role in migraine pathophysiology. For ACE I/D polymorphism, higher frequency of DD genotype (32.35 % vs 15.3 %) and D allele (0.51 vs 0.4) were observed in patients than in controls. Logistic regression analysis revealed a significant association of ACE I/D polymorphism with risk of migraine. However, a direct link of MTHFR C677T polymorphism with migraine risk was not found.
Highlights
Disturbance in vascular functioning pathways has been related to pathophysiology of migraine
The present study investigated the role of MTHFR C677T and Angiotensin converting enzyme (ACE) I/D gene polymorphisms in migraine susceptibility within the population of Jammu province of J&K state
Due to absence of heterozygous and homozygous variant genotypes in control group, we were not able to apply genetic models for evaluating risk or protection conferred by genotype combinations towards migraine progression
Summary
Disturbance in vascular functioning pathways has been related to pathophysiology of migraine. The present study investigated the role of MTHFR C677T and ACE I/D gene polymorphisms in migraine susceptibility within the population of Jammu province of J&K state. Genes which are known to be linked with vascular or endothelial functioning have become prime candidates that may be involved in migraine pathogenesis. The ACE gene has been mapped to chromosome 17 (17q23.3) It has two polymorphic alleles, insertion (I), and the deletion (D) of 287 bp Alu sequence within the intron 16 (Sharma et al, 1998., Kundal et al, 2016). The Deletion allele of ACE gene reported as a strong risk factor for susceptibility of migraine (Paterna et al, 2000; Kowa et al, 2005; Lea et al, 2005).
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