Abstract

It currently remains a puzzle for what signature of natural selection casts in human genome.Mitochondrial DNA (mtDNA) differs from nuclear DNA in many aspects such as lack of recombination and maternal inheritance etc. These essential biological characteristics including the natural selection were detected easily in mtDNA, and thus offer a preponderant and potential tool for the investigation between natural selection and adaptation in human evolutionary history. In this review, we elucidated the progress of relationships between mtDNA specific variation and human evolution based on the mitochondrial genome phylogenesis and analysis of encoding gene variation. Key words: Mitochondrial genome;  Phylogeny;  Encoding gene variation;  Human evolution

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