Relationship of markers of muscle metabolism with the features of diet in patients on hemodialysis

Abstract

Purpose: the Assessing of the relationship of the daily diet of dialysis patients with chronic kidney disease with a change in the levels of myostatin and protein kinase-β in order to determine the areas of potential impact on the development of protein-energy deficiency.Materials and methods: тhe study included 80 patients with chronic kidney disease 5D. All patients underwent laboratory tests and the average daily diet was estimated from 3-day nutrition diaries. MSTN and AKT levels were determined in the blood by ELISA.Results: in the study, the prevalence of PEW was 90%. We have proposed a catabolic muscle tissue index (CMTI), which takes into account the complex effect of the relationship between MSTN and AKT on the development of PEW. The daily calorie and protein in patients were less than recommended. The interconnections of dietary features and markers of catabolism of muscle tissue were determined, which is an area of potential interest in the prevention and progression of PEW and requires further study.Conclusions: correction of the diet of dialysis patients is important for nutritional deficiency and control the catabolic way of the myostatin.