Relationship of interleukin 10 1082 G/A gene polymorphism with the duration of nephrotoxic onset due to anti tuberculosis drugs in multi drug resistant tuberculosis patients

Abstract

Background: The problems of prevention of tuberculosis (TB) are become more complex with the presence of Mycobacterium Tuberculosis which drug resistant called multi drug resistant tuberculosis (MDR-TB). The IL-10 1082 G/A gene polymorphism is associated with the secretion of interleukin 10 (IL-10) as an anti inflammatory cytokine which contributes to the pathogenesis of MDR-TB infection. Management of MDR-TB using an anti TB aminoglycoside drug has a nephrotoxic effects. The protective role of IL-10 from the IL-10 1082 G/A genotype on nephrotoxicity due to kanamycin therapy is still an obstacle. Aims: to determine the relationship between nephrotoxic IL-10 1082 G/A gene polymorphism in patients with MDR-TB after aminoglycoside therapy Method: A retrospective cohort study on MDR-TB patients treated at Dr. Moewardi hospital Surakarta from 2011-2015. Results: The research subjects were 89 patients with MDR TB with IL-10 1082 G/A gene polymorphism. The proportion of IL-10 1082 G/A genotype AA 13.48%, GG 4.49%, and GA 82.02%. Statistical tests found that the GG genotype affect nephrotoxic earliear than the GA genotype and AA genotype. Conclusion: IL-10 1082 G/A gene polymorphism was associated with long onset of nephrotoxic therapy with kanamycin in the management of MDR-TB. Keywords: MDR-TB, IL-10 1082 G/A, nephrotoxic gene polymorphism.