Abstract
BackgroundInsulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness.MethodsThis study included 2560 Korean subjects without a previous history of coronary artery disease, stroke, and malignancies who participated in a community-based cohort study. Arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV).ResultsAll participants were stratified into four groups based on the quartile of the TyG index. The prevalence of metabolic syndrome and diabetes significantly increased with increasing TyG index quartile. The mean baPWV was significantly different among all groups (group I [lowest]: 1421 ± 242 vs. group II: 1480 ± 244 vs. group III: 1534 ± 260 vs. group IV [highest]: 1575 ± 279 cm/s; p < 0.001). The TyG index values were correlated with baPWV (r = 0.224, p < 0.001). Multiple regression analysis showed that age (β = 0.410), male gender (β = 0.051), increased blood pressure (β = 0.266), and TyG index (β = 0.158) were associated with baPWV (p < 0.05, respectively). TyG index was independently related to baPWV in both non-diabetics and diabetics.ConclusionsThe TyG index is independently associated with arterial stiffness in a relatively healthy Korean population.
Highlights
Cardiovascular (CV) disease is a major cause of morbidity and mortality
Previous studies suggested the possibility of a somewhat different atherosclerotic change in diabetics compared to non-diabetics, data on the usefulness of triglyceride glucose (TyG) index on subclinical atherosclerosis according to diabetic status is currently unavailable
All participants were stratified into four groups based on their TyG index levels
Summary
Cardiovascular (CV) disease is a major cause of morbidity and mortality. It is well-established that insulin resistance (IR) is associated with an increased risk of metabolic abnormalities, including hyperglycemia, dyslipidemia, and hypertension [1, 2]. The triglyceride glucose (TyG) index was used as a simple and reliable surrogate marker of IR. There is a paucity of data on the relationship between the TyG index and subclinical atherosclerosis, especially arterial stiffness which has independent prognostic value for the risk of CV events. Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between the triglyceride glucose (TyG) index, which is a simple and reliable surrogate marker for IR, and arterial stiffness
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