Abstract
A sustained-release preparation of S35-labeled prochlorperazine prepared with different in vitro release patterns as determined by the rotating bottle method was administered to human subjects. Urinary recovery of S35 was determined by liquid scintillation counting. Previously published data on sustained-release preparations of phenylpropanolamine and trimeprazine, treated in the same fashion as the prochlorperazine data, are included. For the specific dosage form of each drug, a direct rank relationship was found to exist between in vitro data and the respective in vivo data. A sustained-release preparation of S35-labeled prochlorperazine prepared with different in vitro release patterns as determined by the rotating bottle method was administered to human subjects. Urinary recovery of S35 was determined by liquid scintillation counting. Previously published data on sustained-release preparations of phenylpropanolamine and trimeprazine, treated in the same fashion as the prochlorperazine data, are included. For the specific dosage form of each drug, a direct rank relationship was found to exist between in vitro data and the respective in vivo data.
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