Relationship of in vitro and in vivo approaches on slow appearance rate of starch: a meta‐analysis (1039.10)

Abstract

Objectives: Decreasing glycemic response (GR) is relevant in the prevention of metabolic diseases. High slowly digestible starch (SDS) could be a good candidate to decrease GR. A meta‐analysis of 5 intervention studies evaluates the strength between SDS and GR, and SDS and appearance rate of carbohydrates (Ra) of cereal foods.Methods: The five selected randomised clinical trials included from 12 to 38 non diseased subjects tested cereal products with different SDS content. Meta‐analyses and meta‐regression models were done to synthesize the evidence. The odd ratios (OR) with 95% of confidence for the adjusted random‐effects models investigate the association between SDS and postprandial metabolism as GR, insulin response and Ra.Results: Cereal products containing high SDS (from 9 to 16g/portion) are 4.4 times more likely to generate low GR and 2.6 times more likely to generate low insulin response than cereal products containing low SDS. The link between slow exogenous Ra and high SDS was even stronger with an OR of 14.6. Strong link (69%) was obtained between exogenous Ra and GR.Conclusion: High SDS (> 9g/portion) in cereal foods induced a lower postprandial glycaemic response, through a slower appearance rate of exogenous carbohydrates, and with a concomitant low insulin response. This meta‐analysis reinforces the interest of SDS on its impact on carbohydrate metabolism in order to prevent the risk of metabolic disease genesis.