Abstract
Objective: to assess the relationship of polymorphism of the main genes involved in the pathogenesis of arterial hypertension (AH) with indicators reflecting the state of target organs in the group of patients with arterial hypertension.Material and methods: we examined 100 patients with arterial hypertension who underwent standard diagnostic procedures, as well as molecular genetic research.Results: in patients with arterial hypertension statistically significant associations of AGTR2, GNB3, and NOS3 gene polymorphism with left ventricular hypertrophy, CYP11B2 and NOS3 gene polymorphism with left ventricular diastolic dysfunction, and NOS3 gene polymorphism with increased vascular wall stiffness were found (p < 0.05).Conclusions: the results of the study indicate that patients with arterial hypertension are a genetically heterogeneous group in terms of the relationship of specific gene polymorphism with indicators that characterize the state of target organs. The use of genetic approaches is promising for early screening of patients with arterial hypertension, belonging to the high-risk group, in order to ensure timely and effective organoprotection.
Highlights
Для цитирования: Дроботя Н.В., Арутюнян Л.В., Пироженко А.А., Калтыкова В.В
Objective: to assess the relationship of polymorphism of the main genes involved in the pathogenesis of arterial hypertension (AH) with indicators reflecting the state of target organs in the group of patients with arterial hypertension
Material and methods: we examined 100 patients with arterial hypertension who underwent standard diagnostic procedures, as well as molecular genetic research
Summary
Цель: оценить связь полиморфизма основных генов, участвующих в патогенезе артериальной гипертонии, с показателями, отражающими состояние органов-мишеней в группе больных артериальной гипертонией. Заключение: результаты исследования свидетельствуют о том, что больные артериальной гипертонией представляют собой генетически гетерогенную группу с точки зрения связи конкретного полиморфизма генов с показателями, характеризующими состояние органов-мишеней. Использование генетических подходов представляется перспективным для раннего скрининга больных артериальной гипертонией, относящихся к группе повышенного риска, с целью своевременного обеспечения эффективной органопротекции. Взаимосвязь полиморфизма генов с характером поражения органов-мишеней у больных артериальной гипертонией. Conclusions: the results of the study indicate that patients with arterial hypertension are a genetically heterogeneous group in terms of the relationship of specific gene polymorphism with indicators that characterize the state of target organs. The use of genetic approaches is promising for early screening of patients with arterial hypertension, belonging to the high-risk group, in order to ensure timely and effective organoprotection
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