Relationship of Ferritin, Interleukin-8, and D-Dimer Levels with PaO2/FiO2 Ratio and Mortality in ARDS COVID-19

Abstract

This is an analytic observational study with prospective cohort design. Clinical and laboratories data were collected in Dr. Soetomo Hospital?s COVID-19 isolation room between July and October 2020. PaO2/FiO2 Ratio was derived from calculation: PaO2 divided by FiO2. Mortality obtained from medical record. Spearman test, Mann-Whitney test, and ROC curves were used in statistical analysis. There were 77 patients included in this study, 51.9% were dead. Ferritin levels did not correlate significantly with PaO2/FiO2 Ratio (p=0.769). Median of ferritin in non-survivor vs survivor group was not significantly different (p =0.079). There was a significant correlation between IL-8 and PaO2/FiO2 Ratio (p=0.009; rs=0.298). IL-8 did not different significantly in survivor or non-survivor group (p=0.091). D-Dimer level did not correlate significantly with and PaO2/FiO2 Ratio (p=0.418). Median of D-Dimer in non-survivor group was significantly higher than survivor group (p=0,044). D-Dimer cutoff value as mortality predictor was >1,070 ng/ml. Plasma IL-8 level significantly correlates with PaO2/FiO2 Ratio in ARDS COVID-19 patients. D-Dimer level is useful as a mortality predictor in ARDS COVID-19 patients.