Relationship of experimentally induced intestinal tumors to laxative ingestion.

Abstract

AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Colonic neoplasms are produced in the rat by repeated injection of 3:2′-dimethyl-4-aminodiphenyl. The mechanism presumably is by contact of carcinogen with the mucosal cell. This animal model was used to determine whether change in transit time and stool consistency might alter the induction of colonic neoplasia. Five percent magnesium sulfate solution substituted for drinking water was used to cause decreased transit time and watery diarrhea in a group of animals receiving the carcinogen. No difference was noted in incidence of neoplasia. It is concluded that length of contact time and concentration of carcinogen as induced by laxative ingestion is not a limiting factor in the induction of colonic tumors in the animal model used. References 1 Cleveland, J. C., and Cole, J. W.: Identification of the route of action of the colonic carcinogen 3:2′-dimethyl-4-aminodiphenyl. Surg. Forum 17: 314, 1966. 52nd Clinical Congress, Amer. Coll. Surg. 2 Cleveland, J. C., Litvak, S. F., and Cole, J. W.: Identification of the route of action of the carcinogen 3:2′-dimethyl-4-aminobiphenyl in the induction of intestinal neoplasia. Cancer Research 27: 708, 1967. 3 King, E. S. J., and Varasdi, G.: Experimentally induced tumors of the intestine. New Zeal. J. Surg. 29: 38, 1959. 4 Navarrete-Reyna, A., and Spjut, H. J.: The Effect of colostomy on experimentally produced neoplasms of the colon of the rat. Fed. Proc. 25: 2, 1966. 5 O'Gara, R. W.: Personal communication. 6 Spjut, H. J., and Spratt, J. S.: Endemic and morphologic similarities existing between spontaneous colon neoplasma in man and 3:2′-dimethyl-4-aminobiphenyl induced colonic neoplasms in rats. Ann. Surg. 161: 309, 1965. 7 Walpole, H. L., Williams, H. M. C., and Roberts, D. C.: The carcinogenic action of 4-aminodiphenyl and 3:2′-dimethyl-4-aminodiphenyl. Brit. J. Indust. Med. 9: 255, 1952. 8 Weisberger, J. H.: Carcinoma of the Alimentary Tract. Salt Lake City, University of Utah Press, 1965, p. 114. Citing Literature Volume23, Issue5May 1969Pages 1200-1203 ReferencesRelatedInformation