Relationship of duration of phases of cardiac cycle length as determined in humans by the electrokymograph

Abstract

407 (and by invitation) Philip Y. Paterson, M.D. and Elizabeth Smithwick, M.D. New Orleans, La. (From the Division of Infectious Disease, Department of Medicine, Tulane University School of Medicine.) Allergic encephalomyelitis has been produced in dogs by immunization with homologous brain extracts mixed with adjuvants. The histopathology of the disease resembles that described by others in monkeys but a longer time is required for the development of lesions and the incidence is lower. An antibody has been demonstrated in the serum of immunized dogs which reacts with an antigenic component of normal dog brain and peripheral nerve in complement fixation tests. The relationship between this antigen-antibody system and the experimental disease is not known; all dogs showing demyelination have had antibody but others without lesions have also had antibody. The antigen is demonstrable in aqueous and lipid-solvent extracts of brain. It is present in brain and nerve tissue from other species but not in other organs. It is not demonstrable in newborn dog brain tissue. It is resistant to boiling and to treatment with 10 per cent formalin. It is a component of the acetone-soluble, unsaponifiable fraction of white matter lipids and is separable from cholesterol. Specific immunologic activity may be demonstrated with less than 1 microgram of the partially purified material. Further studies bearing on the nature of this material will be presented. EFFECTS OF POSTURE AND OF COMPRESSION (OF THE NECK ON GLOMERULAR FILTRA:TION. William Viar, M.D. and Thomas Lombardo, M.D. (introduced by T. R. Harrison, M.D.). Dallas, Tex. (From the Department of Medicine, Southwestern Medical College.) The rise in sodium excretion produced by the recumbent position or by compression of the neck in the sitting position is not attended by significant change in glomerular filtration. Alterations in tubular activity must therefore be held responsible. RELATIONSHIP UF DURATION OF PHASES w CARDIAC CYCI.E LENGTH AS DETERMINED IN HUMANS BY THE ELECTROKYMOGRAPH. kathryn Willis, M.D. (introduced by Tin&y R. Harrison, M.D.). Dallas, Tex. (From the Department of Internal Medicine, Southwestern Medical College.) There is a paucity of data in the literature