Relationship of dietary micronutrient intake with fasting plasma glucose and HbA1c: DIALBEST Trial Preliminary Results

Abstract

The objective of this study was to examine the relationship of dietary micronutrient intake with HbA1c and fasting plasma glucose (FPG) in Latino patients with type 2 diabetes in total sample (TS) versus plausible reporters (PR). Demographic information and one 24hr dietary recall was gathered for 159 patients =21 yrs, HbA1c =7, residing in Hartford county (M=25%; F=75%). Participants with reported energy intake (EI) within 1 SD of estimated energy requirement (EER) were called PR; others were implausible reporters (IR). Means for TS; age=56 yrs, BMI=34 kg/m², HbA1c=9.6%, FPG=10.6 mmol/dl (190 mg/dl); were similar to means for PR; age=56 yrs, BMI=34 kg/m², HbA1c=9.5%, FPG=10.2 mmol/dl (183 mg/dl). Mean EITS=1467 kcal and mean EI/EERTS=0.74. Mean EIPR=1834 kcals and mean EI/EERPR was=0.92. FPG was positively correlated with HbA1c in TS (r=0.5) and PR (r=0.6) (p<0.001). In TS, retinol, Vit D, Vit B6, thiamine, riboflavin, niacin, and folate intake were associated with FPG (r = 0.2 to 0.3, p<0.01). In PR, retinol (r = ‐0.03), Mg (r = 0.03) and Vit K (r = 0.03) were associated with FPG (p<0.05). Mean intakes; retinol=306 mcg, Vit K=38 mcg, Mg=277 mg; for PR were below DRI. Findings suggest caution in interpretation of nutrient‐biomarker associations when samples include IR. Funding: Connecticut NIH Export Center of Excellence for Eliminating Health Disparities among Latinos (NIH‐NCMHD grant # P20MD001765).