Relationship of Depression With Executive Functions and Visuospatial Memory in Elderly.

Abstract

Cognitive deficits are a potential part of the clinical picture of depression, especially when it comes to late-life depression. The present study was carried out to establish whether distinctive cognitive deficiencies can be linked with depression in the late-life period, especially in executive functioning, working memory, and visuospatial memory. Our sample consisted of 71 seniors in the age range between 69 and 85 years. A battery of neurocognitive tests was used, including tests of executive functioning (Trail Making Test [TMT], part B, Stroop color word test, semantic word fluency test, and partially Rey-Osterrieth Complex Figure test [ROCF]), tests of attention and working memory (TMT, part A and digit span), and test of visuospatil ability and memory (ROCF). Results demonstrated that depression scores were significantly negatively correlated with scores on Verbal Fluency test, Stroop test, and ROCF immediate copy and recall. Depression was also linked to slower functioning on Trail Making A and Trail Making B subtest. In general, higher depression scores were correlated with lower performance on neuropsychological tests. However, digit span showed no significant correlation with depression. In addition, results of regression analyses revealed that the strongest predictors of depression were performance on the Rey-Osterrieth test-immediate recall and Stroop test. Thus, we could ascertain that difficulties in executive functioning and visuospatial memory are the best predictors of depression in elderly.