Abstract
Carbon monoxide diffusing capacity (D lco ) single breath method was determined at rest and at different grades of exercise. Membrane diffusing capacity (D m) and pulmonary capillary blood volume (V c) were computed. Blood volume increased as severity of exercise increased but Dm remained essentially unchanged. Exercise in the supine position failed to increase D m over the values observed in the erect position. The data suggest that the increase in D l with exercise stems primarily from an increase in capillary volume with minor alteration in exchange area. A change in capillary shape from an elliptical to a circular configuration is postulated to explain these results. Such a geometric change would provide an increase in volume without an increase in surface area.
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