Relationship of D-Dimer, Pt, Aptt, and Albumin with severity and mortality rate in Covid-19 positive patients

Abstract

COVID-19 is a global health problem that is divided into mild, moderate, and severe degrees of severity and a high mortality rate. The coagulopathy system has value in COVID-19 patients. This study aims to determine the relationship and predictive value of d-dimer, PT, aPTT, and albumin with severity and mortality in COVID-19 positive patients. The type of research used is retrospective with a cross-sectional approach. The research data were taken using a simple random sampling technique from the Medical Record Installation of Husada Utama Hospital, Surabaya in August-September 2021. Bivariate relationship data analysis used the Chi-Square test followed by a multivariate logistic regression test with cut-off values ??of D-dimer, PT, aPTT, and albumin each 0.5 g/mL, 14.0 sec. 36.0 seconds and 3.5 g/dL. The results of the chi-square test (? < 0.05) showed the sig value of D-Dimer, PT, aPTT albumin with a severity level of 0.000; 0.000; 0.001; 0.001 while the value of Sig. with a mortality of 0.000; 0.047; 0.239; 0.022. The results of the multivariate logistic regression test with the degree of severity obtained the value of Sig. 0.000; 0.000; 0.021; 0.000 with a [PR] value of 16.7; 4.4; 2.7; 14.4. The results of the multivariate logistic regression test with mortality obtained the value of Sig. 0.000; 0.020; 0.273 with a [PR] value of 26.9; 2.8;1.6. There is a relationship between D-Dimer, PT, aPTT, and albumin with severity and mortality and can be used as a predictor of severity and mortality in COVID-19 patients.