Abstract
BackgroundThe presence of chronic deciduitis (CD) was determined in patients diagnosed with or without chronic endometritis (CE) before pregnancy.ObjectiveTo study the effect of CE on decidua in cases of miscarriage.MethodsDecidual tissue was obtained from the patients who miscarried at the first pregnancy within a year after the diagnosis of the presence or absence of CE. The number and distribution pattern of plasma cells stained with CD138 in decidual tissue in 10 high-power fields (HPFs) was examined. The prevalence of CD diagnosed with four different grade; grade 0, no plasma cell in 10 HPFs, thus Non-CD;grade 1, rare single plasma cells; grade 2, rare clusters or more than 5 single cells total; and grade 3, many plasma cells with more than 5 clusters, were examined and compared between Non-CE and CE.ResultsThe incidence rate of CD of grade2 + 3 was significantly higher in CE than Non-CE (53.8%; 7/13 vs. 0%; 0/13, P < 0.01). Presence of clusters or a number of plasma cells in 10 HPFs of decidua showed a sensitivity of 53.8%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 68.4% for the diagnosis of CE.ConclusionPresence of clusters of plasma cells or five or more of plasma cells in decidua was found in more than half of CE, but not found in Non-CE. When CD with cluster or five or more of plasma cells is confirmed histologically in miscarriage decidual tissue, the presence of CE before the pregnancy should be suspected.
Highlights
The presence of chronic deciduitis (CD) was determined in patients diagnosed with or without chronic endometritis (CE) before pregnancy
The present study focused on chronic deciduitis (CD) for the purpose of histologically examining the effects of CE on the decidua
Grade 1 CD was found in the Non-CE group, and Grade 1, 2, and 3 CD were found in the CE group (Table 1)
Summary
The presence of chronic deciduitis (CD) was determined in patients diagnosed with or without chronic endometritis (CE) before pregnancy. Chronic endometritis (CE) is a slight inflammation of the endometrium that is histologically diagnosed by the presence of plasma cells in the stroma of the endometrium [1,2,3,4,5]. The diagnosis of CD is similar to that of CE, depending histologically on the presence of plasma cells in the decidua [19, 20]. The effect of CE on the decidua was determined by examining for the presence of plasma cells and the incidence of CD, using the decidual tissue of patients who became pregnant but miscarried following diagnosis with or without CE
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
