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Abstract
Although accumulating evidence suggests a higher prevalence of posterior vitreous detachment (PVD) in highly myopic eyes, the relation between ocular biometric features and PVD stages in such eyes remains unclear. Therefore, we enrolled 170 patients with high myopia (axial length ≥ 26.0 mm) to investigate the status of PVD regarding subfoveal choroidal thickness and axial length. Utilising swept-source optical coherence tomography, we classified the PVD status into five stages. The distribution of PVD grades increased as the choroidal thickness decreased and axial length increased (P < 0.01). On adjusting for age and sex, decreased choroidal thickness and increased axial length were associated with more advanced PVD stages: odds ratios with the highest vs. lowest groups were 0.31 (95% confidence interval [CI] 0.09–1.01; Ptrend = 0.009) for choroidal thickness and 5.16 (95% CI 1.34–19.80; Ptrend = 0.002) for axial length. The inverse association between choroidal thickness and PVD status seemed stronger in women than in men (Pinteraction = 0.05). In conclusion, we firstly observed a significant trend of decreased choroidal thickness, along with increased axial length, with increased grade of PVD, particularly among women with highly myopic eyes, suggesting that advanced morphological myopic changes contribute to PVD in middle-aged adults.
Highlights
Accumulating evidence suggests a higher prevalence of posterior vitreous detachment (PVD) in highly myopic eyes, the relation between ocular biometric features and PVD stages in such eyes remains unclear
This study revealed that the prevalence of complete PVD was significantly higher in more advanced myopia, characterised by decreased choroidal thickness and increased axial length, in patients with high myopia aged 20–59 years old
To the best of our knowledge, this is the first study to explore the correlation between choroidal thickness and the advanced PVD grades in the early stages of myopia
Summary
Accumulating evidence suggests a higher prevalence of posterior vitreous detachment (PVD) in highly myopic eyes, the relation between ocular biometric features and PVD stages in such eyes remains unclear. We firstly observed a significant trend of decreased choroidal thickness, along with increased axial length, with increased grade of PVD, among women with highly myopic eyes, suggesting that advanced morphological myopic changes contribute to PVD in middle-aged adults. A case–control study using SS-OCT suggested a significantly earlier onset of partial and complete PVDs in patients with high myopia than in c ontrols[11]. An age- and sex-matched case–control study suggested that the PVD stage was more advanced in eyes with high myopia than in those without high myopia[13]. Independently associated with a myopic shift (i.e. at least a − 0.5 D decrease in spherical equivalent refraction [SER])[19] These findings indicate that choroidal thickness, along with axial length, is an important biometric factor in young patients with myopia
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