Abstract
BackgroundUsing blood specimens from untreated early Parkinson's disease (PD) patients from the DATATOP trial, we found that subjects in the low serum vitamin B12 tertile experienced greater annualized change in ambulatory capacity score, whereas those with moderately elevated (>15 μmol/L) total homocysteine had greater annualized declines in the Mini‐Mental State Exam.MethodsIn this this study we sought to determine whether levels of cerebrospinal fluid (CSF) B12 markers were also associated with progression of PD.ResultsThe annualized change in the UPDRS “walking” item, a component of the ambulatory capacity score, was worse in the low B12 tertile. No association with change in the Mini‐Mental State Exam was seen for those 7% with the highest baseline CSF total homocysteine.ConclusionsIn these untreated early‐PD subjects, low CSF B12 predicted greater worsening of the UPDRS “walking” item, whereas CSF total homocysteine was not associated with progression of cognitive impairment. These findings extend and partially support our findings in serum. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Highlights
Relevant conflicts of interest/financial disclosures: C.W.C. reports research grants from Voyager Therapeutics, Inc, NINDS, and from Michael J
In our recent investigation of vitamin B12 status in untreated early Parkinson’s disease (PD), using 680 baseline blood samples from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) cohort,[1] we found that those subjects with B12 levels in the low tertile developed greater morbidity, as measured by annualized changes in the ambulatory capacity score compared with those in the middle and upper tertiles
cerebrospinal fluid (CSF) analytes showed significant associations with serum analytes, the CSF levels were substantially lower than the serum levels for all except Methylmalonic acid (MMA)
Summary
: Background and Objectives: The purpose of this study was to assess efficacy and safety of a new patterned theta burst stimulation algorithm of DBS with the aim of expanding the therapeutic window and clinical benefit in PD. The purpose of this project was to assess new DBS algorithms by using patterned stimulation techniques
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