Relationship of Baseline Gated Rest SPECT Myocardial Perfusion Imaging to Death and Hospitalization in Heart Failure Patients: Results from the Nuclear Substudy of the HF-ACTION Trial

Abstract

Background: There are currently limited data from large, prospective studies regarding the ability of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI) variables to predict adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejection fraction (EF). We hypothesize that the severity of resting perfusion defects (“myocardial scarring”) as measured by the summed rest score (SRS) by SPECT MPI will be associated with higher rates of adverse outcomes as defined by a composite primary endpoint of all-cause mortality and cardiovascular hospitalization in patients enrolled in the HF-ACTION trial.