Relationship of apathy in acute cerebral infarction and hypersensitivity-C heactive protein, blood uric acid and cognitive impairment

Abstract

Objective To analyze the relationship between apathy in the acute phase of cerebral infarction and acute hypersensitivity-C-reactive protein (hs-CRP), uric acid (UA), and cognitive impairment. Methods Eighty-four cases of cerebral infarction admitted to the People’s Hospital of Jincheng from January 2017 to April 2018 were selected. Within 2 weeks of stroke, the emotional apathy of the patients were assessed by emotional apathy scale, the cognitive, emotional and behavioral aspects respectively. The total score was between 0 and 42 points. The higher the score was, the more serious the apathy was, and the score was more than 14 points, which can be diagnosed as emotional apathy. Simple mental state examination was used to assess the cognitive impairment in patients. At the time of admission and assessment, elbow venous blood was measured for hs-CRP and UA. Results The MAES score ranged from 5 to 31 points, with an average of (11.5±6.3) points, of which 25 patients with≥14 points. The three aspects of cognition, emotion and behavior were evaluated respectively. The hs-CRP and UA levels were higher in the patients with emotional apathy than those in the patients without emotional apathy on admission and during assessment. The patients with emotional apathy had a higher change range of hs-CRP, UA levels than the patients without emotional apathy, and the differences were significant(P<0.05). MAES score is correlated with MMSE, hs-CRP and UA levels at admission (P<0.05). Conclusions Apathy in the acute phase of cerebral infarction is correlated with hs-CRP, UA, and cognitive impairment. The higher the levels of hs-CRP and UA at admission, the more severe the cognitive impairment and the higher the risk of apathy. Key words: Cerebral infarction; Acute phase; Apathy; Hypersensitivity C-reactive protein; Blood uric acid; Cognitive impairment