Relationship of Antral Motility to Gastrin Activity in Surgically Prepared Dogs

Abstract

Chemical secretagogues and insulin-induced vagal stimulation were utilized to evoke gastrin release in dogs prepared with vagally denervated fundic pouches. For comparative purposes a gastrin extract was prepared from hog antral mucosa, using the method of Gillespie and Grossman. Gastrin activity was assessed in terms of the total acid content of periodic samples aspirated from the fundic pouch. Movements of a magnet, affixed surgically to the pyloric antrum, were remotely monitored using a magnetometer. Antral motility was monitored during the stimulation of endogenous gastrin release and the infusion of exogenous gastrin in anesthetized animals. These studies indicated that there is not a direct correlation between endogenous gastrin release and antral motility. The intravenous infusion of exogenous gastrin elicited gastric acid secretion and antral motility; the responses bore a relationship to infusion rate.